Ontology highlight
ABSTRACT:
SUBMITTER: Sehgal BU
PROVIDER: S-EPMC2820731 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Sehgal Bernd U BU DeBiase Phillip J PJ Matzno Sumio S Chew Teng-Leong TL Claiborne Jessica N JN Hopkinson Susan B SB Russell Alan A Marinkovich M Peter MP Jones Jonathan C R JC
The Journal of biological chemistry 20060914 46
Whether alpha6beta4 integrin regulates migration remains controversial. beta4 integrin-deficient (JEB) keratinocytes display aberrant migration in that they move in circles, a behavior that mirrors the circular arrays of laminin (LM)-332 in their matrix. In contrast, wild-type keratinocytes and JEB keratinocytes, induced to express beta4 integrin, assemble laminin-332 in linear tracks over which they migrate. Moreover, laminin-332-dependent migration of JEB keratinocytes along linear tracks is r ...[more]