Ontology highlight
ABSTRACT:
SUBMITTER: Shokeer A
PROVIDER: S-EPMC2820791 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Shokeer Abeer A Mannervik Bengt B
The Journal of biological chemistry 20091218 8
Adaptive responses to novel toxic challenges provide selective advantages to organisms in evolution. Glutathione transferases (GSTs) play a pivotal role in the cellular defense because they are main contributors to the inactivation of genotoxic compounds of exogenous as well as of endogenous origins. GSTs are promiscuous enzymes catalyzing a variety of chemical reactions with numerous alternative substrates. Despite broad substrate acceptance, individual GSTs display pronounced selectivities suc ...[more]