Ontology highlight
ABSTRACT:
SUBMITTER: Ten VS
PROVIDER: S-EPMC2821109 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Ten Vadim S VS Yao Jun J Ratner Veniamin V Sosunov Sergey S Fraser Deborah A DA Botto Marina M Sivasankar Baalasubramanian B Morgan B Paul BP Silverstein Samuel S Stark Raymond R Polin Richard R Vannucci Susan J SJ Pinsky David D Starkov Anatoly A AA
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100201 6
Hypoxic-ischemic (HI) brain injury in infants is a leading cause of lifelong disability. We report a novel pathway mediating oxidative brain injury after hypoxia-ischemia in which C1q plays a central role. Neonatal mice incapable of classical or terminal complement activation because of C1q or C6 deficiency or pharmacologically inhibited assembly of membrane attack complex were subjected to hypoxia-ischemia. Only C1q(-/-) mice exhibited neuroprotection coupled with attenuated oxidative brain inj ...[more]