Ontology highlight
ABSTRACT:
SUBMITTER: Parvanov ED
PROVIDER: S-EPMC2821451 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20091231 5967
Mammalian meiotic recombination, which preferentially occurs at specialized sites called hotspots, ensures the orderly segregation of meiotic chromosomes and creates genetic variation among offspring. A locus on mouse chromosome 17, which controls activation of recombination at multiple distant hotspots, has been mapped within a 181-kilobase interval, three of whose genes can be eliminated as candidates. The remaining gene, Prdm9, codes for a zinc finger containing histone H3K4 trimethylase that ...[more]