Ontology highlight
ABSTRACT:
SUBMITTER: Matallanas D
PROVIDER: S-EPMC2821687 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Matallanas David D Romano David D Yee Karen K Meissl Katrin K Kucerova Lucia L Piazzolla Daniela D Baccarini Manuela M Vass J Keith JK Kolch Walter W O'neill Eric E
Molecular cell 20070901 6
RASSF1A is a tumor suppressor gene that is epigenetically silenced in a wide variety of sporadic human malignancies. Expression of alternative RASSF1 isoforms cannot substitute for RASSF1A-promoted cell-cycle arrest and apoptosis. Apoptosis can be driven by either activating Bax or by activation of MST kinases. The Raf1 proto-oncogene binds to MST2, preventing its activation and proapoptotic signaling. Here we show that key steps in RASSF1A-induced apoptosis are the disruption of the inhibitory ...[more]