Ontology highlight
ABSTRACT:
SUBMITTER: Samali A
PROVIDER: S-EPMC2821749 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Samali Afshin A Fitzgerald Una U Deegan Shane S Gupta Sanjeev S
International journal of cell biology 20100119
The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in the cell. Physiological or pathological processes that disturb protein folding in the endoplasmic reticulum cause ER stress and activate a set of signaling pathways termed the Unfolded Protein Response (UPR). The UPR can promote cellular repair and sustained survival by reducing the load of unfolded proteins through upregulation of chaperones and global attenuation of protein synthesis. Research into ER st ...[more]