Carbon metabolism-mediated myogenic differentiation.
Ontology highlight
ABSTRACT:
SUBMITTER: Bracha AL
PROVIDER: S-EPMC2822028 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Carbon metabolism-mediated myogenic differentiation.
Bracha Abigail L AL Ramanathan Arvind A Huang Sui S Ingber Donald E DE Schreiber Stuart L SL
Nature chemical biology 20100117 3
The role of nutrients and metabolism in cellular differentiation is poorly understood. Using RNAi screening, metabolic profiling and small-molecule probes, we discovered that the knockdown of three metabolic enzymes-phosphoglycerate kinase (Pgk1), hexose-6-phosphate dehydrogenase (H6pd) and ATP citrate lyase (Acl)-induces differentiation of mouse C2C12 myoblasts even in the presence of mitogens. These enzymes and the pathways they regulate provide new targets for the control of myogenic differen ...[more]
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