Repressive BMP2 gene regulatory elements near the BMP2 promoter.
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ABSTRACT:
SUBMITTER: Jiang S
PROVIDER: S-EPMC2822113 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Repressive BMP2 gene regulatory elements near the BMP2 promoter.
Jiang Shan S Chandler Ronald L RL Fritz David T DT Mortlock Douglas P DP Rogers Melissa B MB
Biochemical and biophysical research communications 20100112 2
The level of bone morphogenetic protein 2 (BMP2) profoundly influences essential cell behaviors such as proliferation, differentiation, apoptosis, and migration. The spatial and temporal pattern of BMP2 synthesis, particular in diverse embryonic cells, is highly varied and dynamic. We have identified GC-rich sequences within the BMP2 promoter region that strongly repress gene expression. These elements block the activity of a highly conserved, osteoblast enhancer in response to FGF2 treatment. B ...[more]
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