Ontology highlight
ABSTRACT:
SUBMITTER: Saini Y
PROVIDER: S-EPMC2822559 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Saini Yogesh Y Kim Kyung Y KY Lewandowski Ryan R Bramble Lori A LA Harkema Jack R JR Lapres John J JJ
American journal of physiology. Lung cellular and molecular physiology 20091113 2
Hypoxia plays an important role in development, cellular homeostasis, and pathological conditions, such as cancer and stroke. There is also growing evidence that hypoxia is an important modulator of the inflammatory process. Hypoxia-inducible factors (HIFs) are a family of proteins that regulate the cellular response to oxygen deficit, and loss of HIFs impairs inflammatory cell function. There is little known, however, about the role of epithelial-derived HIF signaling in modulating inflammation ...[more]