Ontology highlight
ABSTRACT:
SUBMITTER: Montange RK
PROVIDER: S-EPMC2822714 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Journal of molecular biology 20091216 3
The SAM-I riboswitch is a cis-acting element of genetic control found in bacterial mRNAs that specifically binds S-adenosylmethionine (SAM). We previously determined the 2.9-A X-ray crystal structure of the effector-binding domain of this RNA element, revealing details of RNA-ligand recognition. To improve this structure, variations were made to the RNA sequence to alter lattice contacts, resulting in a 0.5-A improvement in crystallographic resolution and allowing for a more accurate refinement ...[more]