Ontology highlight
ABSTRACT:
SUBMITTER: Lin CW
PROVIDER: S-EPMC2822732 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Lin Chia-Wei CW Sim Shuyin S Ainsworth Alice A Okada Masayoshi M Kelsch Wolfgang W Lois Carlos C
Neuron 20100101 1
New neurons are added to the adult brain throughout life, but only half ultimately integrate into existing circuits. Sensory experience is an important regulator of the selection of new neurons but it remains unknown whether experience provides specific patterns of synaptic input or simply a minimum level of overall membrane depolarization critical for integration. To investigate this issue, we genetically modified intrinsic electrical properties of adult-generated neurons in the mammalian olfac ...[more]