Ontology highlight
ABSTRACT:
SUBMITTER: Gross H
PROVIDER: S-EPMC2822742 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Gross Henrik H Barth Stephanie S Palermo Richard D RD Mamiani Alfredo A Hennard Christine C Zimber-Strobl Ursula U West Michelle J MJ Kremmer Elisabeth E Grässer Friedrich A FA
Virology 20091206 2
The Epstein-Barr virus (EBV) growth-transforms B-lymphocytes. The virus-encoded nuclear antigen 2 (EBNA2) is essential for transformation and activates gene expression by association with DNA-bound transcription factors such as RBPJkappa (CSL/CBF1). We have previously shown that EBNA2 contains symmetrically dimethylated Arginine (sDMA) residues. Deletion of the RG-repeat results in a reduced ability of the virus to immortalise B-cells. We now show that the RG repeat also contains asymmetrically ...[more]