Local protease signaling contributes to neural tube closure in the mouse embryo.
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ABSTRACT:
SUBMITTER: Camerer E
PROVIDER: S-EPMC2822780 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Local protease signaling contributes to neural tube closure in the mouse embryo.
Camerer Eric E Barker Adrian A Duong Daniel N DN Ganesan Rajkumar R Kataoka Hiroshi H Cornelissen Ivo I Darragh Molly R MR Hussain Arif A Zheng Yao-Wu YW Srinivasan Yoga Y Brown Christopher C Xu Shan-Mei SM Regard Jean B JB Lin Chen-Yong CY Craik Charles S CS Kirchhofer Daniel D Coughlin Shaun R SR
Developmental cell 20100101 1
We report an unexpected role for protease signaling in neural tube closure and the formation of the central nervous system. Mouse embryos lacking protease-activated receptors 1 and 2 showed defective hindbrain and posterior neuropore closure and developed exencephaly and spina bifida, important human congenital anomalies. Par1 and Par2 were expressed in surface ectoderm, and Par2 was expressed selectively along the line of closure. Ablation of G(i/z) and Rac1 function in these Par2-expressing ce ...[more]
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