Ontology highlight
ABSTRACT:
SUBMITTER: Pande M
PROVIDER: S-EPMC2822883 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Pande Mala M Lynch Patrick M PM Hopper John L JL Jenkins Mark A MA Gallinger Steve S Haile Robert W RW LeMarchand Loic L Lindor Noralane M NM Campbell Peter T PT Newcomb Polly A PA Potter John D JD Baron John A JA Frazier Marsha L ML Amos Christopher I CI
Clinical cancer research : an official journal of the American Association for Cancer Research 20100209 4
<h4>Purpose</h4>Lynch syndrome family members with inherited germline mutations in DNA mismatch repair (MMR) genes have a high risk of colorectal cancer (CRC), and cases typically have tumors that exhibit a high level of microsatellite instability (MSI). There is some evidence that smoking is a risk factor for CRCs with high MSI; however, the association of smoking with CRC among those with Lynch syndrome is unknown.<h4>Experimental design</h4>A multicentered retrospective cohort of 752 carriers ...[more]