Ontology highlight
ABSTRACT:
SUBMITTER: Baird NJ
PROVIDER: S-EPMC2822924 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Baird Nathan J NJ Ferré-D'Amaré Adrian R AR
RNA (New York, N.Y.) 20100127 3
Riboswitches are structured mRNA elements that regulate gene expression upon binding specific cellular metabolites. It is thought that the highly conserved metabolite-binding domains of riboswitches undergo conformational change upon binding their cognate ligands. To investigate the generality of such a mechanism, we employed small-angle X-ray scattering (SAXS). We probed the nature of the global metabolite-induced response of the metabolite-binding domains of four different riboswitches that bi ...[more]