Ontology highlight
ABSTRACT:
SUBMITTER: Darragh MR
PROVIDER: S-EPMC2823079 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Darragh Molly R MR Schneider Eric L EL Lou Jianlong J Phojanakong Paul J PJ Farady Christopher J CJ Marks James D JD Hann Byron C BC Craik Charles S CS
Cancer research 20100209 4
The cell surface protease membrane-type serine protease-1 (MT-SP1), also known as matriptase, is often upregulated in epithelial cancers. We hypothesized that dysregulation of MT-SP1 with regard to its cognate inhibitor hepatocyte growth factor activator inhibitor-1 (HAI-1), a situation that increases proteolytic activity, might be exploited for imaging purposes to differentiate malignant from normal tissue. In this study, we show that MT-SP1 is active on cancer cells and that its activity may b ...[more]