Ontology highlight
ABSTRACT:
SUBMITTER: Kolarovic A
PROVIDER: S-EPMC2823299 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Kolarovic Andrej A Schweizer Emma E Greene Emily E Gironda Mark M Pallan Pradeep S PS Egli Martin M Rozners Eriks E
Journal of the American Chemical Society 20091001 41
DNA and RNA oligonucleotides having formacetal internucleoside linkages between uridine and adenosine nucleosides have been prepared and studied using UV thermal melting, osmotic stress, and X-ray crystallography. Formacetal modifications have remarkably different effects on double helical RNA and DNA-the formacetal stabilizes the RNA helix by +0.7 degrees C but destabilizes the DNA helix by -1.6 degrees C per modification. The apparently hydrophobic formacetal has little effect on hydration of ...[more]