Ontology highlight
ABSTRACT:
SUBMITTER: Ruzankina Y
PROVIDER: S-EPMC2823374 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Ruzankina Yaroslava Y Schoppy David W DW Asare Amma A Clark Carolyn E CE Vonderheide Robert H RH Brown Eric J EJ
Nature genetics 20090830 10
Trp53 loss of function has previously been shown to rescue tissue maintenance and developmental defects resulting from DNA damage or DNA-repair gene mutations. Here, we report that p53 deficiency severely exacerbates tissue degeneration caused by mosaic deletion of the essential genome maintenance regulator Atr. Combined loss of Atr and p53 (Trp53(-/-)Atr(mKO)) led to severe defects in hair follicle regeneration, localized inflammation (Mac1(+)Gr1(+) infiltrates), accelerated deterioration of th ...[more]