Ontology highlight
ABSTRACT:
SUBMITTER: Tung JY
PROVIDER: S-EPMC2823465 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Tung Jung-Yu JY Yang Chih-Wei CW Chou Shao-Wen SW Lin Chien-Chih CC Sun Yuh-Ju YJ
The Journal of biological chemistry 20091130 5
Tubulointerstitial nephritis is a cardinal renal manifestation of leptospirosis. LipL32, a major lipoprotein and a virulence factor, locates on the outer membrane of the pathogen Leptospira. It evades immune response by recognizing and adhering to extracellular matrix components of the host cell. The crystal structure of Ca(2+)-bound LipL32 was determined at 2.3 A resolution. LipL32 has a novel polyD sequence of seven aspartates that forms a continuous acidic surface patch for Ca(2+) binding. A ...[more]