Ontology highlight
ABSTRACT:
SUBMITTER: Rickman C
PROVIDER: S-EPMC2823538 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Rickman Colin C Duncan Rory R RR
The Journal of biological chemistry 20090911 6
In neuronal and hormonal release, regulated exocytosis requires an essential set of proteins: the soluble N-ethylmaleimide sensitive-factor attachment receptor proteins (SNAREs) syntaxin 1, SNAP-25, VAMP, and their regulator, Munc18. Recently, it was found that Munc18-1 can interact with syntaxin 1 through distinct mechanisms: an inhibitory mode enveloping syntaxin (mode 1), sequestering it from SNARE protein interactions, and direct binding to an evolutionarily conserved N-terminal peptide of s ...[more]