Ontology highlight
ABSTRACT:
SUBMITTER: Juranic N
PROVIDER: S-EPMC2823543 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Juranic Nenad N Atanasova Elena E Filoteo Adelaida G AG Macura Slobodan S Prendergast Franklyn G FG Penniston John T JT Strehler Emanuel E EE
The Journal of biological chemistry 20091207 6
Using solution NMR spectroscopy, we obtained the structure of Ca(2+)-calmodulin (holoCaM) in complex with peptide C28 from the binding domain of the plasma membrane Ca(2+)-ATPase (PMCA) pump isoform 4b. This provides the first atomic resolution insight into the binding mode of holoCaM to the full-length binding domain of PMCA. Structural comparison of the previously determined holoCaM.C20 complex with this holoCaM.C28 complex supports the idea that the initial binding step is represented by (hol ...[more]