Skeletal muscle phenotypically converts and selectively inhibits metastatic cells in mice.
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ABSTRACT:
SUBMITTER: Parlakian A
PROVIDER: S-EPMC2823787 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Skeletal muscle phenotypically converts and selectively inhibits metastatic cells in mice.
Parlakian Ara A Gomaa Iman I Solly Sounkary S Arandel Ludovic L Mahale Alka A Born Gustav G Marazzi Giovanna G Sassoon David D
PloS one 20100218 2
Skeletal muscle is rarely a site of malignant metastasis; the molecular and cellular basis for this rarity is not understood. We report that myogenic cells exert pronounced effects upon co-culture with metastatic melanoma (B16-F10) or carcinoma (LLC1) cells including conversion to the myogenic lineage in vitro and in vivo, as well as inhibition of melanin production in melanoma cells coupled with cytotoxic and cytostatic effects. No effect is seen with non-tumorigenic cells. Tumor suppression as ...[more]
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