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Association of paternal age and risk for major congenital anomalies from the National Birth Defects Prevention Study, 1997 to 2004.

ABSTRACT: The objective of this study was to examine the associations between paternal age and birth defects of unknown etiologies while carefully controlling for maternal age.By using 1997 to 2004 data from the National Birth Defects Prevention Study, we fit logistic regression models with paternal and maternal age as continuous variables while adjusting for demographic and other factors.Elevated odds ratios (ORs) for each year increase in paternal age were found for cleft palate (OR. 1.02, 95% confidence interval [95% CI], 1.00-1.04), diaphragmatic hernia (OR, 1.04; 95% CI, 1.02-1.06), right ventricular outflow tract obstruction (OR, 1.03; 95% CI, 1.01-1.04), and pulmonary valve stenosis (OR, 1.02, 95% CI, 1.01-1.04). At younger paternal ages, each year increase in paternal age correlated with increased odds of having offspring with encephalocele, cataract, esophageal atresia, anomalous pulmonary venous return, and coarctation of the aorta, but these increased odds were not observed at older paternal ages. The effect of paternal age was modified by maternal age for gastroschisis, omphalocele, spina bifida, all orofacial clefts, and septal heart defects.Our findings suggest that paternal age may be a risk factor for some multifactorial birth defects.

SUBMITTER: Green RF

PROVIDER: S-EPMC2824069 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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Association of paternal age and risk for major congenital anomalies from the National Birth Defects Prevention Study, 1997 to 2004.

Green Ridgely Fisk RF Devine Owen O Crider Krista S KS Olney Richard S RS Archer Natalie N Olshan Andrew F AF Shapira Stuart K SK

Annals of epidemiology 20100106 3

<h4>Purpose</h4>The objective of this study was to examine the associations between paternal age and birth defects of unknown etiologies while carefully controlling for maternal age.<h4>Methods</h4>By using 1997 to 2004 data from the National Birth Defects Prevention Study, we fit logistic regression models with paternal and maternal age as continuous variables while adjusting for demographic and other factors.<h4>Results</h4>Elevated odds ratios (ORs) for each year increase in paternal age were ...[more]

PMID: 20056435

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Project description:BackgroundGastroschisis is particularly prevalent among offspring of young women and has increased over recent decades. Although previous studies suggest that maternal alcohol consumption is associated with increased gastroschisis risk, none have explored whether maternal age modifies that association.ObjectiveThe objective of the study was to evaluate associations between self-reported maternal periconceptional alcohol consumption (1 month prior through the third month after conception) and risk of gastroschisis among offspring, by maternal age.MethodsWe used data from the National Birth Defects Prevention Study (NBDPS), a multi-site population-based case-control study. The analysis included 1450 gastroschisis cases and 11,829 unaffected liveborn controls delivered during 1997-2011 in ten US states. We estimated adjusted odds ratios (aOR) and 95% confidence intervals (CI) for the individual and joint effects of alcohol consumption and young maternal age at delivery (<25 years vs ≥25 years) on gastroschisis risk. We estimated the relative excess risk due to interaction (RERI) to quantify additive interaction.ResultsPericonceptional alcohol consumption was common regardless of maternal age (women <25 years: cases 38.8%, controls 29.3%; women ≥25: cases 43.5%, controls 39.5%). Compared with women ≥25 years who did not consume alcohol, we observed increased risk of gastroschisis among women <25 years, with higher estimates among those who consumed alcohol (women <25 years who did not consume alcohol. aOR 5.90, 95% CI 4.89, 7.11; women <25 years who did consume alcohol: aOR 8.21, 95% CI 6.69, 10.07). Alcohol consumption among women ≥25 years was not associated with gastroschisis (aOR 1.12, 95% CI 0.88, 1.42). This suggests super-additive interaction between alcohol consumption and maternal age (RERI -2.19, 95% CI 1.02, 3.36).ConclusionsPericonceptional alcohol consumption may disproportionately increase risk of gastroschisis among young mothers. Our findings support public health recommendations to abstain from alcohol consumption during pregnancy.

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Association of paternal age and risk for major congenital anomalies from the National Birth Defects Prevention Study, 1997 to 2004.

Publications

Association of paternal age and risk for major congenital anomalies from the National Birth Defects Prevention Study, 1997 to 2004.

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