Association of paternal age and risk for major congenital anomalies from the National Birth Defects Prevention Study, 1997 to 2004.

ABSTRACT:

Purpose

The objective of this study was to examine the associations between paternal age and birth defects of unknown etiologies while carefully controlling for maternal age.

Methods

By using 1997 to 2004 data from the National Birth Defects Prevention Study, we fit logistic regression models with paternal and maternal age as continuous variables while adjusting for demographic and other factors.

Results

Elevated odds ratios (ORs) for each year increase in paternal age were found for cleft palate (OR. 1.02, 95% confidence interval [95% CI], 1.00-1.04), diaphragmatic hernia (OR, 1.04; 95% CI, 1.02-1.06), right ventricular outflow tract obstruction (OR, 1.03; 95% CI, 1.01-1.04), and pulmonary valve stenosis (OR, 1.02, 95% CI, 1.01-1.04). At younger paternal ages, each y

SUBMITTER: Green RF 

PROVIDER: S-EPMC2824069 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature