Ontology highlight
ABSTRACT:
SUBMITTER: Steward CA
PROVIDER: S-EPMC2824108 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Steward Charles A CA Humphray Sean S Plumb Bob B Jones Matthew C MC Quail Michael A MA Rice Stephen S Cox Tony T Davies Rob R Bonfield James J Keane Thomas M TM Nefedov Michael M de Jong Pieter J PJ Lyons Paul P Wicker Linda L Todd John J Hayashizaki Yoshihide Y Gulban Omid O Danska Jayne J Harrow Jen J Hubbard Tim T Rogers Jane J Adams David J DJ
Genomics 20091110 2
Non-obese diabetic (NOD) mice spontaneously develop type 1 diabetes (T1D) due to the progressive loss of insulin-secreting beta-cells by an autoimmune driven process. NOD mice represent a valuable tool for studying the genetics of T1D and for evaluating therapeutic interventions. Here we describe the development and characterization by end-sequencing of bacterial artificial chromosome (BAC) libraries derived from NOD/MrkTac (DIL NOD) and NOD/ShiLtJ (CHORI-29), two commonly used NOD substrains. T ...[more]