Ontology highlight
ABSTRACT:
SUBMITTER: Stagg J
PROVIDER: S-EPMC2824381 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Stagg John J Divisekera Upulie U McLaughlin Nicole N Sharkey Janelle J Pommey Sandra S Denoyer Delphine D Dwyer Karen M KM Smyth Mark J MJ
Proceedings of the National Academy of Sciences of the United States of America 20100104 4
Extracellular adenosine is a potent immunosuppressor that accumulates during tumor growth. We performed proof-of-concept studies investigating the therapeutic potential and mechanism of action of monoclonal antibody (mAb)-based therapy against CD73, an ecto-enzyme overexpressed on breast-cancer cells that catalyzes the dephosphorylation of adenosine monophosphates into adenosine. We showed that anti-CD73 mAb therapy significantly delayed primary 4T1.2 and E0771 tumor growth in immune-competent m ...[more]