Ontology highlight
ABSTRACT:
SUBMITTER: Lee SO
PROVIDER: S-EPMC2824452 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Lee Seong-Ok SO Cho Kwangmin K Cho Sunglim S Kim Ilkwon I Oh Changhoon C Ahn Kwangseog K
The EMBO journal 20091126 2
The human cytomegalovirus glycoprotein US2 induces dislocation of MHC class I heavy chains from the endoplasmic reticulum (ER) into the cytosol and targets them for proteasomal degradation. Signal peptide peptidase (SPP) has been shown to be integral for US2-induced dislocation of MHC class I heavy chains although its mechanism of action remains poorly understood. Here, we show that knockdown of protein disulphide isomerase (PDI) by RNA-mediated interference inhibited the degradation of MHC clas ...[more]