Ontology highlight
ABSTRACT:
SUBMITTER: Wendler F
PROVIDER: S-EPMC2824459 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Wendler Franz F Gillingham Alison K AK Sinka Rita R Rosa-Ferreira Cláudia C Gordon David E DE Franch-Marro Xavier X Peden Andrew A AA Vincent Jean-Paul JP Munro Sean S
The EMBO journal 20091126 2
Genetic screens in the yeast Saccharomyces cerevisiae have identified many proteins involved in the secretory pathway, most of which have orthologues in higher eukaryotes. To investigate whether there are additional proteins that are required for secretion in metazoans but are absent from yeast, we used genome-wide RNA interference (RNAi) to look for genes required for secretion of recombinant luciferase from Drosophila S2 cells. This identified two novel components of the secretory pathway that ...[more]