Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction.
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ABSTRACT:
SUBMITTER: Saez-Rodriguez J
PROVIDER: S-EPMC2824489 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction.
Saez-Rodriguez Julio J Alexopoulos Leonidas G LG Epperlein Jonathan J Samaga Regina R Lauffenburger Douglas A DA Klamt Steffen S Sorger Peter K PK
Molecular systems biology 20091201
Large-scale protein signalling networks are useful for exploring complex biochemical pathways but do not reveal how pathways respond to specific stimuli. Such specificity is critical for understanding disease and designing drugs. Here we describe a computational approach--implemented in the free CNO software--for turning signalling networks into logical models and calibrating the models against experimental data. When a literature-derived network of 82 proteins covering the immediate-early respo ...[more]
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