Palindrome-mediated chromosomal translocations in humans.
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ABSTRACT:
SUBMITTER: Kurahashi H
PROVIDER: S-EPMC2824556 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Publications
Palindrome-mediated chromosomal translocations in humans.
Kurahashi Hiroki H Inagaki Hidehito H Ohye Tamae T Kogo Hiroshi H Kato Takema T Emanuel Beverly S BS
DNA repair 20060710 9-10
Recently, it has emerged that palindrome-mediated genomic instability contributes to a diverse group of genomic rearrangements including translocations, deletions, and amplifications. One of the best studied examples is the recurrent t(11;22) constitutional translocation in humans that has been well documented to be mediated by palindromic AT-rich repeats (PATRRs) on chromosomes 11q23 and 22q11. De novo examples of the translocation are detected at a high frequency in sperm samples from normal h ...[more]
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