Ontology highlight
ABSTRACT:
SUBMITTER: Shyn SI
PROVIDER: S-EPMC2824618 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
The Psychiatric clinics of North America 20100301 1
Efforts to unlock the biology of major depressive disorder (MDD) are proceeding on multiple fronts. In this article, the authors review the current understanding of epidemiological evidence for a heritable component to MDD risk, as well as recent advances in linkage, candidate gene, and genome-wide association analyses of MDD and related disease subtypes and endophenotypes. While monoamine signaling has preoccupied the bulk of scientific investigation to date, nontraditional gene candidates such ...[more]