Unknown

Dataset Information

0

Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).


ABSTRACT: The polycystic ovary syndrome (PCOS), a common endocrine disorder in women of child-bearing age, mainly characterised by chronic anovulation and hyperandrogenism, is often associated with insulin resistance (IR) and obesity. Its etiology and the role of IR and obesity in PCOS are not fully understood. We examined the influence of validated genetic variants conferring susceptibility to obesity and/or type 2 diabetes mellitus (T2DM) on metabolic and PCOS-specific traits in patients with PCOS.We conducted an association study in 386 patients with PCOS (defined by the Rotterdam-criteria) using single nucleotide polymorphisms (SNPs) in or in proximity to the fat mass and obesity associated gene (FTO), insulin-induced gene-2 (INSIG2), transcription factor 7-like 2 gene (TCF7L2) and melanocortin 4 receptor gene (MC4R). To compare the effect of FTO obesity risk alleles on BMI in patients with PCOS to unselected females of the same age range we genotyped 1,971 females from the population-based KORA-S4 study (Kooperative Gesundheitsforschung im Raum Augsburg, Survey 4).The FTO risk allele was associated with IR traits and measures of increased body weight. In addition, the TCF7L2 SNP was associated with body weight traits. For the SNPs in the vicinity of INSIG2 and MC4R and for the other examined phenotypes there was no evidence for an association. In PCOS the observed per risk allele effect of FTO intron 1 SNP rs9939609 on BMI was +1.56 kg/m2, whereas it was +0.46 kg/m2 in females of the same age range from the general population as shown previously.The stronger effect on body weight of the FTO SNP in PCOS might well have implications for the etiology of the disease.

SUBMITTER: Tan S 

PROVIDER: S-EPMC2824654 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).

Tan Susanne S   Scherag André A   Janssen Onno Eilard OE   Hahn Susanne S   Lahner Harald H   Dietz Tiina T   Scherag Susann S   Grallert Harald H   Vogel Carla Ivane Ganz CI   Kimmig Rainer R   Illig Thomas T   Mann Klaus K   Hebebrand Johannes J   Hinney Anke A  

BMC medical genetics 20100121


<h4>Background</h4>The polycystic ovary syndrome (PCOS), a common endocrine disorder in women of child-bearing age, mainly characterised by chronic anovulation and hyperandrogenism, is often associated with insulin resistance (IR) and obesity. Its etiology and the role of IR and obesity in PCOS are not fully understood. We examined the influence of validated genetic variants conferring susceptibility to obesity and/or type 2 diabetes mellitus (T2DM) on metabolic and PCOS-specific traits in patie  ...[more]

Similar Datasets

| S-EPMC3899374 | biostudies-literature
| S-EPMC6314644 | biostudies-other
| S-EPMC7808627 | biostudies-literature
| S-EPMC3917751 | biostudies-literature
| S-EPMC5563909 | biostudies-literature
| S-EPMC8255636 | biostudies-literature
| S-EPMC6206814 | biostudies-other
| S-EPMC7583345 | biostudies-literature
| S-EPMC6295958 | biostudies-literature
| S-EPMC3024473 | biostudies-literature