Biomimetic nanowire coatings for next generation adhesive drug delivery systems.
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ABSTRACT:
SUBMITTER: Fischer KE
PROVIDER: S-EPMC2824765 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Biomimetic nanowire coatings for next generation adhesive drug delivery systems.
Fischer Kathleen E KE Alemán Benjamin J BJ Tao Sarah L SL Hugh Daniels R R Li Esther M EM Bünger Mark D MD Nagaraj Ganesh G Singh Parminder P Zettl Alex A Desai Tejal A TA
Nano letters 20090201 2
Without bioadhesive delivery devices, complex compounds are typically degraded or cleared from mucosal tissues by the mucous layer.While some chemically modified, microstructured surfaces have been studied in aqueous environments,adhesion due to geometry alone has not been investigated. Silicon nanowire-coated beads show significantly better adhesion than those with targeting agents under shear, and can increase the lift-off force 100-fold. We have shown that nanowire coatings, paired with epith ...[more]
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