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Synthesis, Structure and Biological Activity of Amide-Functionalized Titanocenyls: Improving their Cytotoxic Properties.

ABSTRACT: Nine amide-functionalized titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2) was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2) showed that titanium is in a pseudo tetrahedral geometry and contains a Ti-O(amide) coordination. In principle, Ti-O coordination should provide more hydrolytic stability to the corresponding titanocenyls than titanocene dichloride. The cytotoxic activities of these amide-functionalized titanocenyls on HT-29 colon cancer cell line were determined by MTT assay to elucidate structure-activity relationship. All complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities.

SUBMITTER: Gao LM

PROVIDER: S-EPMC2824910 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature

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Synthesis, Structure and Biological Activity of Amide-Functionalized Titanocenyls: Improving their Cytotoxic Properties.

Gao Li Ming LM Matta Jaime J Rheingold Arnold L AL Meléndez Enrique E

Journal of organometallic chemistry 20091201 26

Nine amide-functionalized titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2) was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2) showed that titanium is in a pseudo tetrahedral geometry and contains a Ti-O(amide) coordination. In principle, Ti-O coordination should provide more hydrolytic stability to the corresponding titanocenyls tha ...[more]

PMID: 20177431

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