Ontology highlight
ABSTRACT:
SUBMITTER: Kawabe H
PROVIDER: S-EPMC2825371 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Neuron 20100201 3
Nedd4-1 is a "neuronal precursor cell expressed and developmentally downregulated protein" and among the most abundant E3 ubiquitin ligases in mammalian neurons. In analyses of conventional and conditional Nedd4-1-deficient mice, we found that Nedd4-1 plays a critical role in dendrite formation. Nedd4-1, the serine/threonine kinase TNIK, and Rap2A form a complex that controls Nedd4-1-mediated ubiquitination of Rap2A. Ubiquitination by Nedd4-1 inhibits Rap2A function, which reduces the activity o ...[more]