Ontology highlight
ABSTRACT:
SUBMITTER: Arcemisbehere L
PROVIDER: S-EPMC2825429 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Arcemisbéhère Laure L Sen Tuhinadri T Boudier Laure L Balestre Marie-Noëlle MN Gaibelet Gérald G Detouillon Emilie E Orcel Hélène H Mendre Christiane C Rahmeh Rita R Granier Sébastien S Vivès Corinne C Fieschi Franck F Damian Marjorie M Durroux Thierry T Banères Jean-Louis JL Mouillac Bernard B
The Journal of biological chemistry 20091221 9
Accumulating evidence indicates that G protein-coupled receptors can assemble as dimers/oligomers but the role of this phenomenon in G protein coupling and signaling is not yet clear. We have used the purified leukotriene B(4) receptor BLT2 as a model to investigate the capacity of receptor monomers and dimers to activate the adenylyl cyclase inhibitory G(i2) protein. For this, we overexpressed the recombinant receptor as inclusion bodies in the Escherichia coli prokaryotic system, using a human ...[more]