Ontology highlight
ABSTRACT:
SUBMITTER: Breuer P
PROVIDER: S-EPMC2825449 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Breuer Peter P Haacke Annette A Evert Bernd O BO Wüllner Ullrich U
The Journal of biological chemistry 20100111 9
Expansion of a polymorphic polyglutamine segment is the common denominator of neurodegenerative polyglutamine diseases. The expanded proteins typically accumulate in large intranuclear inclusions and induce neurodegeneration. However, the mechanisms that determine the subcellular site and rate of inclusion formation are largely unknown. We found that the conserved putative nuclear localization sequence Arg-Lys-Arg-Arg, which is retained in a highly aggregation-prone fragment of ataxin-3, did not ...[more]