Ontology highlight
ABSTRACT:
SUBMITTER: Masharani UB
PROVIDER: S-EPMC2825571 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Masharani Umesh B UB Becker Joseph J
Expert opinion on biological therapy 20100301 3
<h4>Importance of the field</h4>Type 1 diabetes mellitus (T1D) is a T-cell mediated autoimmune disease with selective destruction of beta cells. Immunological interventions are directed at arresting the loss of beta-cell function with the promise that this will make it easier for patients to control their glucose levels.<h4>Areas covered in this review</h4>This review provides a summary of the preclinical and clinical research published between 1992 and 2009 using teplizumab and other anti-CD3 a ...[more]