BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer.
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ABSTRACT:
SUBMITTER: Clark-Knowles KV
PROVIDER: S-EPMC2825770 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
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BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer.
Clark-Knowles Katherine V KV O'Brien Anna M AM Weberpals Johanne I JI
Journal of oncology 20100222
In sporadic epithelial ovarian cancer (EOC), the inactivation of BRCA1 through various mechanisms is a relatively common event. BRCA1 protein dysfunction results in the breakdown of various critical pathways in the cell, notably, the DNA damage response and repair pathway. Tumors from patients with BRCA1 germline mutations have an increased sensitivity to DNA damaging chemotherapeutic agents, such as cisplatin, due to defective DNA repair. Thus, inhibiting BRCA1 in sporadic EOC using novel targe ...[more]
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