Ontology highlight
ABSTRACT:
SUBMITTER: Cairns M
PROVIDER: S-EPMC2825997 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Cairns M M Cisse B B Sokhna C C Cames C C Simondon K K Ba E H EH Trape J-F JF Gaye O O Greenwood B M BM Milligan P J M PJ
Antimicrobial agents and chemotherapy 20100111 3
Sulfadoxine-pyrimethamine with amodiaquine (SP-AQ) is a highly efficacious regimen for intermittent preventive treatment to prevent malaria in children (IPTc), but the amodiaquine component is not always well tolerated. We determined the association between amodiaquine dosage by body weight and mild adverse events (AEs) and investigated whether alternative age-based regimens could improve dosing accuracy and tolerability, using data from two trials of IPTc in Senegal, one in which AQ dose was de ...[more]