Ontology highlight
ABSTRACT:
SUBMITTER: Waheed AA
PROVIDER: S-EPMC2826043 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Journal of virology 20091230 6
We previously reported that human immunodeficiency virus type 1 (HIV-1) develops resistance to the cholesterol-binding compound amphotericin B methyl ester (AME) by acquiring mutations (P203L and S205L) in the cytoplasmic tail of the transmembrane envelope glycoprotein gp41 that create cleavage sites for the viral protease (PR). In the present study, we observed that a PR inhibitor-resistant (PIR) HIV-1 mutant is unable to efficiently cleave the gp41 cytoplasmic tail in P203L and S205L virions, ...[more]