Ontology highlight
ABSTRACT:
SUBMITTER: Kang W
PROVIDER: S-EPMC2826126 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Kang Wenfei W Wong Li Chin LC Shi Song-Hai SH Hébert Jean M JM
The Journal of neuroscience : the official journal of the Society for Neuroscience 20091101 46
During corticogenesis, the balance between the self-renewal of radial glial stem cells and the production of their descendent progenitor cells is essential in generating the correct size and cell composition of the neocortex. How the stem-to-progenitor cell transition is regulated is poorly understood. FGFs are commonly implicated in promoting proliferation of neural precursor cells, but it is unclear how they exert their effects on stem cells, progenitor cells, or both in vivo. Here, three FGF ...[more]