Ontology highlight
ABSTRACT:
SUBMITTER: Escher N
PROVIDER: S-EPMC2826342 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Escher Niko N Ernst Günther G Melle Christian C Berndt Alexander A Clement Joachim H JH Junker Kerstin K Friedrich Karlheinz K Guntinas-Lichius Orlando O von Eggeling Ferdinand F
Diagnostic pathology 20100128
In carcinoma tissues, genetic and metabolic changes not only occur at the tumor cell level, but also in the surrounding stroma. This carcinoma-reactive stromal tissue is heterogeneous and consists e.g. of non-epithelial cells such as fibroblasts or fibrocytes, inflammatory cells and vasculature-related cells, which promote carcinoma growth and progression of carcinomas. Nevertheless, there is just little knowledge about the proteomic changes from normal connective tissue to tumor stroma. In the ...[more]