Cost-effectiveness of breast MR imaging and screen-film mammography for screening BRCA1 gene mutation carriers.

ABSTRACT:

Purpose

To evaluate the clinical effectiveness and cost-effectiveness of screening strategies in which MR imaging and screen-film mammography were used, alone and in combination, in women with BRCA1 mutations.

Materials and methods

Because this study did not involve primary data collection from individual patients, institutional review board approval was not needed. By using a simulation model, we compared three annual screening strategies for a cohort of 25-year-old BRCA1 mutation carriers, as follows: (a) screen-film mammography, (b) MR imaging, and (c) combined MR imaging and screen-film mammography (combined screening). The model was used to estimate quality-adjusted life-years (QALYs) and lifetime costs. Incremental cost-effectiveness ratios were calculated. Input param

SUBMITTER: Lee JM 

PROVIDER: S-EPMC2826703 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature