Ontology highlight
ABSTRACT:
SUBMITTER: Alt-Holland A
PROVIDER: S-EPMC2827766 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Alt-Holland Addy A Shamis Yulia Y Riley Kathleen N KN DesRochers Teresa M TM Fusenig Norbert E NE Herman Ira M IM Garlick Jonathan A JA
The Journal of investigative dermatology 20080605 10
The link between loss of cell-cell adhesion, the activation of cell migration, and the behavior of intraepithelial (IE) tumor cells during the early stages of skin cancer progression is not well understood. The current study characterized the migratory behavior of a squamous cell carcinoma cell line (HaCaT-II-4) upon E-cadherin suppression in both 2D, monolayer cultures and within human skin equivalents that mimic premalignant disease. The migratory behavior of tumor cells was first analyzed in ...[more]