Ontology highlight
ABSTRACT:
SUBMITTER: Singh K
PROVIDER: S-EPMC2828269 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20091201 12
Immune responses to citrullinated neoantigens and clinical efficacy of costimulation blockade indicate a general defect in maintaining T cell tolerance in rheumatoid arthritis (RA). To examine whether TCR threshold calibration contributes to disease pathogenesis, signaling in RA T cells was quantified. RA patients had a selective increase in ERK phosphorylation compared with demographically matched controls due to a mechanism distal of Ras activation. Increased ERK responses included naive and m ...[more]