Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.
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ABSTRACT:
SUBMITTER: Conroy JL
PROVIDER: S-EPMC2828325 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.
Conroy Jennie L JL Fang Cheng C Gu Jun J Zeitlin Scott O SO Yang Weizhu W Yang Jun J VanAlstine Melissa A MA Nalwalk Julia W JW Albrecht Phillip J PJ Mazurkiewicz Joseph E JE Snyder-Keller Abigail A Shan Zhixing Z Zhang Shao-Zhong SZ Wentland Mark P MP Behr Melissa M Knapp Brian I BI Bidlack Jean M JM Zuiderveld Obbe P OP Leurs Rob R Ding Xinxin X Hough Lindsay B LB
Nature neuroscience 20100207 3
To assess the importance of brain cytochrome P450 (P450) activity in mu opioid analgesic action, we generated a mutant mouse with brain neuron-specific reductions in P450 activity; these mice showed highly attenuated morphine antinociception compared with controls. Pharmacological inhibition of brain P450 arachidonate epoxygenases also blocked morphine antinociception in mice and rats. Our findings indicate that a neuronal P450 epoxygenase mediates the pain-relieving properties of morphine. ...[more]
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