Ontology highlight
ABSTRACT:
SUBMITTER: Shcherbik N
PROVIDER: S-EPMC2828747 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Shcherbik Natalia N Wang Minshi M Lapik Yevgeniya R YR Srivastava Leena L Pestov Dimitri G DG
EMBO reports 20100108 2
Most transcripts in growing cells are ribosomal RNA precursors (pre-rRNA). Here, we show that in mammals, aberrant pre-rRNA transcripts generated by RNA polymerase I (Pol I) are polyadenylated and accumulate markedly after treatment with low concentrations of actinomycin D (ActD), which blocks the synthesis of full-length rRNA. The poly(A) polymerase-associated domain-containing protein 5 is required for polyadenylation, whereas the exosome is partly responsible for the degradation of the short ...[more]