Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC2828816 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20091101 5954
Pathogen recognition by T cells is dependent on their exquisite specificity for self-major histocompatibility complex (MHC) molecules presenting a bound peptide. Although this specificity results from positive and negative selection of developing T cells in the thymus, the relative contribution of these two processes remains controversial. To address the relation between the selecting peptide-MHC complex and the specificity of mature T cells, we generated transgenic mice that express a single pe ...[more]