Ontology highlight
ABSTRACT:
SUBMITTER: Funahashi Y
PROVIDER: S-EPMC2828996 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Funahashi Yasuhiro Y Shawber Carrie J CJ Vorontchikhina Marina M Sharma Anshula A Outtz Hasina H HH Kitajewski Jan J
Journal of angiogenesis research 20100126 1
Notch is a critical regulator of angiogenesis and arterial specification. We show that ectopic expression of activated Notch1 induces endothelial morphogenesis in human umbilical vein endothelial cells (HUVEC) in a VEGFR-1-dependent manner. Notch1-mediated upregulation of VEGFR-1 in HUVEC increased their responsiveness to the VEGFR-1 specific ligand, Placental Growth Factor (PlGF). In mice and human endothelial cells, inhibition of Notch signaling resulted in decreased VEGFR-1 expression during ...[more]