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Notch regulates the angiogenic response via induction of VEGFR-1.


ABSTRACT: Notch is a critical regulator of angiogenesis and arterial specification. We show that ectopic expression of activated Notch1 induces endothelial morphogenesis in human umbilical vein endothelial cells (HUVEC) in a VEGFR-1-dependent manner. Notch1-mediated upregulation of VEGFR-1 in HUVEC increased their responsiveness to the VEGFR-1 specific ligand, Placental Growth Factor (PlGF). In mice and human endothelial cells, inhibition of Notch signaling resulted in decreased VEGFR-1 expression during VEGF-A-induced neovascularization. In summary, we show that Notch1 plays a role in endothelial cells by regulating VEGFR-1, a function that may be important for physiological and pathological angiogenesis.

SUBMITTER: Funahashi Y 

PROVIDER: S-EPMC2828996 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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Notch regulates the angiogenic response via induction of VEGFR-1.

Funahashi Yasuhiro Y   Shawber Carrie J CJ   Vorontchikhina Marina M   Sharma Anshula A   Outtz Hasina H HH   Kitajewski Jan J  

Journal of angiogenesis research 20100126 1


Notch is a critical regulator of angiogenesis and arterial specification. We show that ectopic expression of activated Notch1 induces endothelial morphogenesis in human umbilical vein endothelial cells (HUVEC) in a VEGFR-1-dependent manner. Notch1-mediated upregulation of VEGFR-1 in HUVEC increased their responsiveness to the VEGFR-1 specific ligand, Placental Growth Factor (PlGF). In mice and human endothelial cells, inhibition of Notch signaling resulted in decreased VEGFR-1 expression during  ...[more]

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