Ontology highlight
ABSTRACT:
SUBMITTER: Storr M
PROVIDER: S-EPMC2829088 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Storr Martin M Emmerdinger Dominik D Diegelmann Julia J Pfennig Simone S Ochsenkühn Thomas T Göke Burkhard B Lohse Peter P Brand Stephan S
PloS one 20100226 2
<h4>Background</h4>Recent evidence suggests a crucial role of the endocannabinoid system, including the cannabinoid 1 receptor (CNR1), in intestinal inflammation. We therefore investigated the influence of the CNR1 1359 G/A (p.Thr453Thr; rs1049353) single nucleotide polymorphism (SNP) on disease susceptibility and phenotype in patients with ulcerative colitis (UC) and Crohn's disease (CD).<h4>Methods</h4>Genomic DNA from 579 phenotypically well-characterized individuals was analyzed for the CNR1 ...[more]